Maitreyi S. Joshi

This study identifies eight small-molecule enhancers of circadian rhythm amplitude in both central and peripheral clocks through a drug repurposing screen and ex vivo validation.

The paper shows RPTPγ suppresses promigratory EGFR signaling by redox regulation, enabling phosphorylation responses to low EGF levels while blocking spontaneous signaling.

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.