Philippe I. H. Bastiaens

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

This paper introduces a synthetic active-matter polymer system where each monomer stores an internal state, enabling autonomous remodelling through dynamic instability.

This paper develops a reversible Opto-Chemical system to activate KRASG12V signaling with near single-cell precision and demonstrates its effects on epithelial transformation.

This study uses a chemical-optogenetic approach to control β-catenin activity in mouse small intestinal organoids, revealing persistent aberrant phenotypes and altered differentiation during homeostasis.

This study shows that EGF and EREG ligands regulate proliferation and differentiation in mouse intestinal organoids by modulating EGFR endocytosis and surface expression.

This study investigates laser-induced heating in cryogenic nanoscopy and identifies factors that prevent devitrification under high power illumination.

The paper shows RPTPγ suppresses promigratory EGFR signaling by redox regulation, enabling phosphorylation responses to low EGF levels while blocking spontaneous signaling.

This paper describes a synthetic membrane system that undergoes self-organized shape changes in response to light cues through a light-inducible signaling system and microtubule dynamics.

The paper shows that spatial regulation of Rheb's GTPase cycle by PDE{delta} and Arl2-GTP controls mTORC1 activation in response to growth factors.

The paper develops a FRET-based sensor to study EGFR conformational changes and identifies an autocatalytic mechanism in EGFR activation.

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.