Geert‐Jan van Gemert

Controlled human infection with Plasmodium falciparum-infected mosquito bites elicits antibodies against mosquito salivary protein SG1L3

The paper identifies human antibodies against a mosquito salivary protein, SG1L3, that binds to Plasmodium falciparum sporozoites but does not block infection.

A silent intergenic locus for efficient and versatile transgene expression in Plasmodium falciparum

The paper identifies a silent intergenic locus in Plasmodium falciparum that allows stable transgene expression without disrupting native genes, enabling versatile genetic engineering.

Expelling of P. falciparum sporozoites by Anopheles stephensi mosquitoes during repeated feeding

The paper measures sporozoite expulsion in mosquitoes during repeated feeding and finds similar sporozoite inoculation intensity in subsequent attempts.

Deep behavioral phenotyping of pathogen infected mosquitoes reveals species-specific behavior changes enhancing transmission

This study uses deep learning to analyze mosquito behavior changes after infection, finding species-specific effects that could impact disease transmission.

Quantifying sporozoite inoculum dynamics with the SpitGrid reveals temporal decay and behavioral determinants of Plasmodium transmission

This study uses the SpitGrid platform to measure sporozoite inoculum dynamics in Plasmodium-infected mosquitoes, revealing temporal patterns and behavioral factors influencing transmission.

Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts

The paper identifies Wnt signaling as critical for Plasmodium falciparum liver schizont maturation by using a novel medium to maintain hepatocyte functionality and analyze host-parasite interactions.

Pfs230 Domain 12 is a potent malaria transmission-blocking vaccine candidate

This study identifies Pfs230 Domain 12 as a potent malaria transmission-blocking vaccine candidate that induces antibodies reducing parasite transmission to mosquitoes.

The role of MICOS in organizing mitochondrial cristae in malaria parasites

This study identifies two MICOS components in malaria parasites and shows they are involved in crista junction organization but not initial cristae formation.

An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs

The paper develops an in vitro and in vivo platform for testing malaria transmission-blocking drugs using engineered Plasmodium falciparum gametocytes and humanized mice.

AlbuMAX supplemented media induces the formation of transmission-competent P. falciparum gametocytes

This study shows that AlbuMAX supplemented media increases the production of transmission-competent Plasmodium falciparum gametocytes compared to serum.

Comparative Clustering (CompaCt) of eukaryote complexomes identifies novel interactions and sheds light on protein complex evolution

CompaCt integrates complexome profiling data across species to identify conserved and species-specific protein complexes and interactions, improving characterization through comparative analysis.

Comparative assessment of mosquito size and receptiveness to P. falciparum infection of two rearing procedures for Anopheles mosquitoes

This study compares two mosquito rearing methods for Anopheles stephensi to improve homogeneity and parasite receptiveness for malaria research.