Tobias Spielmann

A new class of lipid transfer proteins is required for the recycling of lipids from the P. falciparum digestive vacuole

The paper identifies PfTUPA, a novel lipid transfer protein in Plasmodium falciparum essential for lipid recycling from the digestive vacuole.

Characterization of Host Cell Cytosol-filled Vesicles in the Human Malaria Parasite Plasmodium falciparum

This study characterizes Hb-filled vesicles (HbVs) in Plasmodium falciparum, identifying their morphology, molecular composition, and a Rab-regulatory component involved in endosomal transport.

Kelch13 stochastics determine drug survival in resistant malaria parasites

The paper shows that stochastic variation in K13 protein levels determines drug survival in genetically identical malaria parasites, explaining why only some survive artemisinin treatment.

A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites

This study identifies PfVPS13L1 as a critical lipid transfer protein in malaria parasites that facilitates lipid transfer from the ER to the inner membrane complex, essential for schizogony.

A system for functional studies of the major virulence factor of malaria parasites

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

Protein landscape of the chromatin states in the malaria parasite Plasmodium falciparum

The paper presents a proteomic characterization of chromatin states in Plasmodium falciparum using proximity-labelling approaches, identifying 214 proteins and validating new chromatin components and functions.

Malaria parasite HOPS/CORVET complexes are critical for endocytosis and invasion organelles function

This study shows that HOPS/CORVET complexes are essential for malaria parasite endocytosis and invasion organelle function, with distinct roles in different developmental stages.

CUT&Tag and DiBioCUT&Tag enable investigation of the AT-rich and dynamic epigenome of Plasmodium falciparum from low input samples.

The paper introduces CUT&Tag and DiBioCUT&Tag methods to profile the epigenome of Plasmodium falciparum from low-input samples, improving upon ChIP-seq limitations.

PMRT1, a Plasmodium specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development

The paper investigates six membrane transporters in Plasmodium falciparum, finding four essential for asexual development and one essential for gametocytogenesis.

Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite Plasmodium falciparum

This study characterizes ApiATs in Plasmodium falciparum, showing their localization to the parasite plasma membrane and partial redundancy in asexual proliferation but not gametocytogenesis.