Bruce E. Kirkpatrick

This study investigates cardiac myofibril remodeling in Burmese pythons during digestion using multi-omics approaches, revealing post-translational modifications as key to increased contractility.

This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.

This study shows that a synthetic hydrogel enables crypt formation in intestinal organoids without exogenous laminin, revealing insights into mechanical and matricellular signaling.

This study shows PTEN suppresses myofibroblast activation in valvular interstitial cells by promoting quiescence and reducing stiffness-induced activation.

This study uses bottlebrush polymer hydrogels to show how strain-stiffening affects hMSC protrusion formation and mechanosensing.