Yan Chen

This study identifies ALKBH5 as a regulator of hepatic gluconeogenesis through m6A-mediated stabilization of Ogt mRNA, showing its therapeutic potential in type 2 diabetes.

This study shows that inactivating a uORF in the Gata4 gene in mice leads to increased GATA4 translation and cardiac hypertrophy.

The paper reports cryo-EM structures of RXFP4-Gi complexes with INSL5 and agonists, revealing a unique peptide-binding mechanism and subtype selectivity determinants.

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.