Author

Omar M. Hedaya

University of Rochester MedicineORCID 0000-0002-5635-660XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Feng JiangiD· 3 shared Peng YaoiD· 3 shared Eng-Soon KhoriD· 2 shared Jiangbin WuiD· 2 shared Aleksandr Ivanov· 1 shared Christoph PröscheliD· 1 shared David H. MathewsiD· 1 shared Jack L. Schwartz· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Feng JiangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice

Omar M. Hedaya, Feng Jiang, Uday K. Baliga, Aleksandr Ivanov, Si Chen, Jack L. Schwartz, Yui Kawakami, Yan Chen, Peng Yao

This study shows that inactivating a uORF in the Gata4 gene in mice leads to increased GATA4 translation and cardiac hypertrophy.

bioRxiv · May 18, 2025 · PreprintBiochemistry

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Omar M. Hedaya, Kadiam C. Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, Eng-Soon Khor, Mingyi Zhu, David H. Mathews, Christoph Pröschel, Peng Yao

The paper identifies dsRNA structures in uORFs that regulate translation and shows ASO targeting can modulate mORF translation and reduce cardiac hypertrophy.

Nature Communications · Oct 3, 2023Peer-reviewedMolecular Biology

RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression

Feng Jiang, Omar M. Hedaya, Eng-Soon Khor, Jiangbin Wu, Matthew Auguste, Peng Yao

This study identifies PRRC2B as an RNA binding protein that regulates translation of specific mRNAs, including cell cycle regulators, and inhibits cell proliferation by affecting G1/S phase transition.

Nucleic Acids Research · May 1, 2023Peer-reviewedMolecular Biology