Kornel Labun

The paper uses ribosome profiling to study translation changes in synaptoneurosomes from rat cortical tissue after group 1 mGluR activation, showing increased translation of synaptic and ribosomal protein mRNAs.

This paper introduces a dual-guide CRISPR-Cas13 system that improves specificity for single-nucleotide variant detection without reducing sensitivity.

This study uses RCP-seq to analyze translation initiation dynamics in mouse brain tissues, revealing SSU poising and uORF effects on translational efficiency.

This paper presents a T cell gene correction pipeline using CRISPR/Cas9 and HDR to correct monogenic mutations in IEI models, achieving up to 80% bi-allelic editing with no detectable off-target effects.

CHOPOFF improves CRISPR off-target detection by addressing limitations in symbolic alignments and introducing efficient data structures for accurate and fast prediction.

The paper introduces SMS-seq, a method to analyze RNA structure at the single-molecule level, revealing structural dependencies, breathing, and ensembles.

The paper evaluates DNA repair protein-Cas9 fusions for improving CRISPR editing efficiency, finding that most require optimization for specific cell types and genomic loci.

ORFik is an R/Bioconductor toolkit for analyzing translation data, supporting multiple high-throughput assays and providing over 30 translation-related metrics.

The paper identifies conserved ribosome stall sites across multiple species using ribosome profiling data, finding that specific amino acids facilitate stalling in RNA processing genes.

tailfindr estimates poly(A) tail length from Oxford Nanopore long-read sequencing data without alignment, enabling poly(A) analysis in RNA and DNA sequencing.

ampliCan provides precise quantification and visualization of genome editing events, outperforming existing tools in benchmark tests.