Håkon Tjeldnes

The paper shows EWSR1::FLI1 fusion drives the production of cancer-specific neoproteins in Ewing sarcoma, revealing a reversible dark proteome with therapeutic potential.

The paper uses ribosome profiling to study translation changes in synaptoneurosomes from rat cortical tissue after group 1 mGluR activation, showing increased translation of synaptic and ribosomal protein mRNAs.

CHOPOFF improves CRISPR off-target detection by addressing limitations in symbolic alignments and introducing efficient data structures for accurate and fast prediction.

This paper introduces Ribosome Decision Graphs (RDGs) to represent eukaryotic RNA translation complexity, enabling analysis of translation patterns and genetic variation effects.

ORFik is an R/Bioconductor toolkit for analyzing translation data, supporting multiple high-throughput assays and providing over 30 translation-related metrics.

The paper characterizes the transcriptome-wide dynamics of translation initiation stages in a higher eukaryote and identifies regulators at each step.