Fangyuan Gao

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study uses multimodal optical imaging to reveal spatial metabolic changes in aging mouse retinas, showing altered NADH/NADPH ratios, collagen remodeling, and lipid dynamics.

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

This study shows the Greenland shark retains a functional visual system adapted to dim light, with intact rod-based vision genes and no retinal degeneration despite its age.

This study shows that supplementing aged mice with 24:5n-3, a product of ELOVL2, improves visual function and reduces AMD-related protein accumulation, suggesting ELOVL2 as a therapeutic target for age-related vision loss.

This study shows that elovl2 is essential for proper lipid composition and visual function in zebrafish, as its inactivation leads to altered lipid levels and visual behavior.