Hyehyun Kim

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study uses a rat primary cortical tri-culture model to show that microglia in co-culture with neurons and astrocytes more effectively clear amyloid-beta and exhibit altered motility compared to co-culture or mono-culture.

This study compares neural network activity in tri-cultures and co-cultures of cortical neurons, astrocytes, and microglia, finding that tri-cultures better mimic in vivo neuroinflammatory responses and have a more accurate E/I ratio.