Lingyan Shi

REDCAT maps single-cell type-specific metabolic activities in tissues using multimodal all-optical imaging, revealing metabolic specialization and reprogramming in immune and liver tissues.

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study uses multimodal optical imaging to reveal spatial metabolic changes in aging mouse retinas, showing altered NADH/NADPH ratios, collagen remodeling, and lipid dynamics.

This study identifies a Notch-dependent lipid metabolic program in Drosophila glia that enhances hypoxia resistance by shifting from glucose to acetate-derived lipid synthesis.

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

NetTracer3D provides a tool for analyzing 3D tissue maps from diverse datasets, enabling network-based exploration of spatial relationships and tissue organization.

The paper introduces SuMMIT-SRS, a multiplexed metabolic imaging technique, and demonstrates its application in various cell types to study metabolic rewiring.

The paper presents a 3D multi-omic framework to detect and characterize ovarian cancer precursors in fallopian tubes, identifying TP53 mutations in microscopic lesions.

This paper presents a multimodal imaging approach to characterize metabolic changes in bronchopulmonary dysplasia, revealing altered lipid distributions and collagen remodeling in affected tissues.

This paper uses label-free imaging to analyze biomolecular and morphological features of diabetic kidney tissue in 2D and 3D, revealing distinct markers not previously observed.

The paper introduces far-red chemigenetic kinase activity biosensors enabling five-color multiplexing, 4D imaging, and super-resolution via STED microscopy.

This study shows that engineered nanotopographies create temporary nuclear membrane openings, enabling molecular exchange without cell penetration.

The paper investigates how traumatic brain injury (TBI) increases mitochondria-associated ER membranes (MAMs) and C99 levels, linking these changes to Alzheimer's disease (AD) through lipid metabolism alterations.

This study shows that isoflurane induces initial calcium increases then suppression in cerebrovascular endothelial cells, disrupting vascular tone during anesthesia.