Hongje Jang

REDCAT maps single-cell type-specific metabolic activities in tissues using multimodal all-optical imaging, revealing metabolic specialization and reprogramming in immune and liver tissues.

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study uses multimodal optical imaging to reveal spatial metabolic changes in aging mouse retinas, showing altered NADH/NADPH ratios, collagen remodeling, and lipid dynamics.

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

The paper introduces SuMMIT-SRS, a multiplexed metabolic imaging technique, and demonstrates its application in various cell types to study metabolic rewiring.