Sadat Shafi

Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

Selective targeting of Plasmodium falciparum hexose transporter by phytochemical Ginsenoside Rg1 disrupts glucose metabolism and block development of parasite

This study identifies Ginsenoside Rg1 as a PfHT1 inhibitor that disrupts glucose metabolism and inhibits growth of both ART-sensitive and resistant Plasmodium falciparum parasites.

Evaluation of Immunopharmacological Efficacy of Live Leishmania donovani Overexpressing Ld_ζ1domain for Protection Against Experimental Human Visceral Leishmaniasis

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.