Robert R. Stickels

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

The paper uses mtDNA mutations to trace clonal relationships of innate immune cells in cancer, showing myeloid clones are linked to monocytes and have distinct epigenetic profiles.

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.

This paper introduces PERFF-seq, a method to profile rare cell states via scRNA-seq by enriching for specific RNA transcripts, demonstrating its application in immune and brain tissues.

The paper identifies a synonymous mtDNA variant that affects codon-anticodon affinity and shows its impact on cellular fitness in immune cells.

This study uses Slide-seqV2 to identify disease-specific cell neighborhoods and pathways in human and mouse kidneys.

The paper generates a single-cell RNA-seq and ATAC-seq atlas of the developing mouse neocortex and reconstructs developmental trajectories to infer gene regulatory programs and identify lineage-specific developmental abnormalities.

The paper improves Slide-seq technology to enhance mRNA capture sensitivity, enabling high-resolution spatial transcriptomics in mouse tissues.

Slide-seq measures genome-wide expression in complex tissues at 10-micron resolution.