Author

Xiaodong Guan

Peking UniversityORCID 0000-0002-1290-3827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Mengling ZhangiD· 2 shared Qian Peter SuiD· 2 shared Yujie SuniD· 2 shared Boxin XueiD· 1 shared Cheng Li· 1 shared Dongyi XuiD· 1 shared Guohong LiiD· 1 shared Haizhen LongiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Mengling ZhangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsCell ReportsPeer-reviewedMar 1, 2026

Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

Mengling Zhang, Wenxue Zhao, Zhiguang Xiao…·Yujie Sun

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

1 citation

humanDNA methylation

𝕏 PostBluesky

GenomicsGenome biologyPeer-reviewedJul 12, 2021

Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency

Yongzheng Li, Boxin Xue, Mengling Zhang…·Yujie Sun

This study uses super-resolution imaging to show that replication origins are preferentially fired at the periphery of TADs due to chromatin re-organization linked to transcription and CTCF.

36 citations

spatial transcriptomicsexperimental assay

𝕏 PostBluesky