Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency
Yongzheng Li, Boxin Xue, Mengling Zhang, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun
This study uses super-resolution imaging to show that replication origins are preferentially fired at the periphery of TADs due to chromatin re-organization linked to transcription and CTCF.
Genome biology · Jul 12, 2021Peer-reviewedGenomics