Cheng Zhang

The paper introduces DIMPLE, a scalable qPCR primer design algorithm that enables 10,000+ primers in a single reaction, achieving low VAF detection and multiplex applications.

The paper uses in situ imaging to show that mtDNA selection in Drosophila ovaries is driven by replication competition, not active elimination.

This paper describes a bacterial Argonaute (MhAgo) with eight cleavage activities, capable of using all four guide types for DNA and RNA cleavage, showing high activity and diverse guide preferences.

This study uses ctDNA analysis to identify genetic mutations and monitor residual disease in NK/T lymphoma patients, finding KMT2D mutations correlate with poor prognosis and treatment response.