Author

Amika Singla

The University of Texas Southwestern Medical CenterORCID 0000-0002-9454-9111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Baoyu CheniD· 3 shared Daniel A. KrameriD· 3 shared Ezra BursteiniD· 3 shared Chigozie NgokaiD· 2 shared Daniel J. BoeschiD· 2 shared Emre E. TureriD· 2 shared Ran SongiD· 2 shared Alka DiwakeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

Baoyu ChenORCID

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3 papers

Recent·Most cited

Phosphoinositide regulation by the CCC complex promotes phagosome maturation and host defense

Hannes Buck, Qi Liu, Amika Singla, Daniel A. Kramer, Rodrigo Pereyria, Wan-Ru Lee, Wesley B Burford, Jianyi Yin, Ariel Davis, Shuai Tan, Baoyu Chen, Luis Sifuentes-Dominguez, Neal M. Alto, Jen Liou, Ezra Burstein

This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.

bioRxiv · Jul 16, 2026 · PreprintCell Biology

The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis

Ran Song, Chigozie Ngoka, Amika Singla, Daniel A. Kramer, Alka Diwaker, Daniel J. Boesch, Qi Liu, James J. Moresco, Bruce Beutler, Hans‐Christian Reinecker, Ezra Burstein, Baoyu Chen, Emre E. Turer

This study identifies the Rab32-LRMDA-Retriever complex as essential for endolysosomal trafficking in innate immune cells, maintaining intestinal immune homeostasis.

bioRxiv · Jul 16, 2025 · PreprintImmunology

Structural basis for Retriever-SNX17 assembly and endosomal sorting

Amika Singla, Daniel J. Boesch, Ho Yee Joyce Fung, Chigozie Ngoka, Avery S. Enriquez, Ran Song, Daniel A. Kramer, Yan Han, Esther Banarer, Andrew Lemoff, Puneet Juneja, Daniel D. Billadeau, Xiaochen Bai, Zhe Chen, Emre E. Turer, , Baoyu Chen

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

bioRxiv · Mar 12, 2024Biochemistry