Phosphoinositide regulation by the CCC complex promotes phagosome maturation and host defense
Hannes Buck, Qi Liu, Amika Singla, Daniel A. Kramer, Rodrigo Pereyria, Wan-Ru Lee, Wesley B Burford, Jianyi Yin, Ariel Davis, Shuai Tan, Baoyu Chen, Luis Sifuentes-Dominguez, Neal M. Alto, Jen Liou, Ezra Burstein
This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.
bioRxiv · Jul 16, 2026 · PreprintCell Biology