Ezra Burstein

This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.

This study shows B3GNT7 regulates colonic mucus glycosylation, protects against colitis and infection, and has a distinct function from other B3GNT family members.

This study shows that type I interferon signaling promotes mucosal inflammation in colitis models, with IFNAR1 inhibition protecting against experimental colitis.

This study identifies the Rab32-LRMDA-Retriever complex as essential for endolysosomal trafficking in innate immune cells, maintaining intestinal immune homeostasis.

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.