Author

Guodong Tie

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:DNA methylation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ramesh A. ShivdasaniiD· 4 shared Ruiyang HeiD· 3 shared Judith KraiczyiD· 2 shared Onur EskiocakiD· 2 shared Semir BeyaziD· 2 shared Swarnabh BhattacharyaiD· 2 shared Adrianna MaglieriiD· 1 shared Aybuke Alici-GaripcaniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCell Biology

Ramesh A. ShivdasaniORCID

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Author profile →

4 papers

Recent·Most cited

A unique intestinal epithelial cell that expresses canonical lymphoid genes

Swarnabh Bhattacharya, Krithika Badarinath, Guodong Tie, Pratik N.P. Singh, Onur Eskiocak, Ruiyang He, Bin Bao, Su‐Hyung Lee, Scott B. Snapper, Kun Huang, James R. Goldenring, Semir Beyaz, Ramesh A. Shivdasani

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

bioRxiv · Oct 26, 2026 · PreprintCell Biology

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice

Masataka Suzuki, Yuko Hasegawa, Hailong Zhang, Zhu Liang, Guodong Tie, Ramesh A. Shivdasani, Matthew K. Waldor

This study shows IL-22 promotes mucus-secreting cells in the small intestine, protecting mice from cholera by reducing V. cholerae colonization.

Nature Microbiology · Jun 3, 2026Peer-reviewedMicrobiology

Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation

Swarnabh Bhattacharya, Guodong Tie, Pratik Narendra Pratap Singh, Ermanno Malagola, Onur Eskiocak, Ruiyang He, Judith Kraiczy, Wei Gu, Yakov Perlov, Aybuke Alici-Garipcan, Semir Beyaz, Timothy Cragin Wang, Qiao Zhou, Ramesh A. Shivdasani

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

Cell stem cell · Feb 8, 2025Peer-reviewedCell Biology

Delineation and birth of a multi-layer intestinal stem cell niche

Neil McCarthy, Guodong Tie, Shariq Madha, Ruiyang He, Judith Kraiczy, Adrianna Maglieri, Ramesh A. Shivdasani

The paper identifies the adult mouse intestinal stem cell niche as a multi-layered structure with distinct mesenchymal and smooth muscle cell populations that regulate ISC proliferation and differentiation.

Developmental Cell · Mar 15, 2023Peer-reviewedDevelopmental Biology