Matthew K. Waldor

This paper presents two new antibody-recruiting molecule (ARM) strategies to combat multidrug-resistant bacterial infections using synthetic peptides and dimeric antibiotics.

Matched liver and colon RNA-seq timeseries during Citrobacter rodentium infection in mice reveal an intimin-dependent hepatic cytokine burst at 3 days that tracks serum cytokine kinetics.

The paper constructs a urinary microbiome catalog and identifies antimicrobial peptides from it that inhibit uropathogenic E. coli.

This study shows IL-22 promotes mucus-secreting cells in the small intestine, protecting mice from cholera by reducing V. cholerae colonization.

This study profiles tRNA modifications in different life stages of Trypanosoma cruzi and finds that hydroxywybutosine modification levels regulate metacyclogenesis.

This study investigates how serotype differences in Vibrio cholerae O1 affect pathogenicity, finding that O1 antigen methylation enhances colonization and resistance to antimicrobial peptides.

The paper introduces MultiCAST, a high-throughput CRISPR-associated transposon system for bacterial gene disruption, enabling rapid and scalable genetic screens using amplicon sequencing.

The paper shows that anoxia activates the CRISPR-Cas system in the mouse intestine via the Fnr regulator, suggesting an adaptation for microbial defense.

This paper shows that IscR, an iron-sulfur cluster sensor, regulates virulence gene expression in Yersinia pseudotuberculosis by responding to iron and oxygen levels, with mutations altering infection dynamics.

This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.

The paper investigates codon usage bias and its relationship with protein expression in Trypanosoma cruzi by integrating tRNA sequencing and transcriptomic data.

This study models Pseudomonas aeruginosa gastrointestinal carriage in mice using vancomycin pretreatment and identifies the stomach as a major barrier to colonization.

InducTn-seq improves transposon mutagenesis by enabling temporal control of transposition, generating diverse mutants and quantifying gene fitness across essential and non-essential genes.

This study shows that reduced motility in Vibrio cholerae decreases inter-animal transmission, while increased motility enhances transmission efficiency in mice.

This study shows that lethal Streptococcus suis serotype 2 infection in mice is driven by widened lymph node bottlenecks and the virulence factor suilysin, leading to systemic bacterial spread.

This study tracks Klebsiella pneumoniae dissemination from the lung using barcoding, revealing two distinct patterns of bacterial spread and their associated host and bacterial factors.

This study identifies the Mla pathway as critical for Vibrio cholerae re-expansion from stationary phase by maintaining energy homeostasis and preventing outer membrane vesicle shedding.

This paper quantifies Salmonella enterica serovar Typhimurium population dynamics in mice using a barcoded library, revealing bottlenecks, compartmentalization, and dissemination patterns.

The paper identifies a large conjugative plasmid that promotes multispecies biofilm formation in the gut microbiota, enhancing resilience to environmental stressors.

This study shows that peripheral serotonergic neurons affect gut motility and anxiety-like behavior, suggesting potential therapeutic targets.