Jonathan A. Oler

Extended amygdala function is governed by threat probability, not uncertainty

The paper challenges the canonical model of anxiety by showing that threat probability, not uncertainty, is more strongly associated with threat anticipation and EA regions.

The development of trait anxiety in nonhuman primates during the first year of life

This study tracks anxious temperament development in nonhuman primates over their first year, finding linear increases and stable individual differences in threat-related behaviors and cortisol levels.

DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates

This study shows that activating the amygdala in young nonhuman primates using DREADDs increases anxiety-like behaviors, suggesting a model for studying human anxiety disorders.

Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early Life Anxious Temperament

The paper identifies 528 AT-related transcripts in rhesus monkey CeL neurons, including PKCδ, and shows their projection to BSTLd, suggesting a primate circuit relevant to anxiety.