Michael Michaelides

This study shows that Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19, affecting NAD+/NADH metabolism and mitochondrial activity.

This study shows early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males, with receptor downregulation after alcohol exposure negating these differences.

This study identifies neurometabolic differences in rats associated with heroin addiction vulnerability and social seeking using FDG-PET imaging and behavioral assays.

This study investigates how D2 autoreceptors influence vulnerability to cocaine use disorder by using cell-type-specific genetic manipulations in mice.

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

This paper uses computational methods to model how nitazene derivatives bind to the mu-opioid receptor, identifying key binding modes and interactions.

The paper shows that subanesthetic ketamine induces opioid-dependent neurophysiological and behavioral effects in male, but not female, rats.

This study identifies AHAPV neurons as glutamatergic neurons that promote escape behavior in mice through projections to the PMD and downstream brain regions.

This paper introduces photoactivatable opioid drugs for in vivo photopharmacology, enabling rapid, localized manipulation of opioid receptors and associated behaviors.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

This study shows that activating the amygdala in young nonhuman primates using DREADDs increases anxiety-like behaviors, suggesting a model for studying human anxiety disorders.

This study shows that activating the anterior hypothalamic area in mice triggers compulsive grooming behavior and reveals its functional connectivity with the ventromedial hypothalamus.

This study shows that synaptic Zn2+ enhances cocaine's effects on striatal dopamine neurotransmission and behavior by increasing DAT binding and altering locomotor responses.

The paper develops new DREADD agonists and a PET radiotracer for improved neuronal activity manipulation and noninvasive projection mapping in neurotheranostics.

The paper demonstrates high-accuracy decoding of complex visual scenes from neuronal calcium responses using neural networks in mice.