Author

Frances M. Brodsky

Institute of Structural and Molecular BiologyORCID 0000-0002-1334-9258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Agnel Praveen JosephiD· 1 shared Alice Burke· 1 shared Alyce McClellaniD· 1 shared Andrea BenazzoiD· 1 shared George T. BatesiD· 1 shared Iain MathiesoniD· 1 shared Joshua GreigiD· 1 shared Kamila KamudaiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

Agnel Praveen JosephORCID

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2 papers

Recent·Most cited

Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter

George T. Bates, Will P. Bultitude, Joshua Greig, Alyce McClellan, Nikos Pinotsis, Pallavi Ramsahye, Wingyan Skyla Siu, Kamila Kamuda, Riccardo Zenezini Chiozzi, Konstantinos Thalassinos, Snezana Djordjević, Frances M. Brodsky

The paper identifies an alternatively-spliced form of CHC17 (CHC17-SAS) that compensates for the absence of CHC22 in some vertebrates, enabling GLUT4 trafficking.

bioRxiv · Sep 7, 2026 · PreprintCell Biology

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

Matteo Fumagalli, Stéphane M. Camus, Yoan Diekmann, Alice Burke, Marine D. Camus, Paul J. Norman, Agnel Praveen Joseph, Laurent Abi‐Rached, Andrea Benazzo, Rita Rasteiro, Iain Mathieson, Maya Topf, Peter Parham, Mark Thomas, Frances M. Brodsky

The paper examines the genetic diversity of CHC22 clathrin and its impact on glucose metabolism, finding that a variant is less effective at controlling GLUT4 traffic and is more common in farming populations.

eLife · Jun 3, 2019Peer-reviewedGenetics