Author

Wingyan Skyla Siu

University College LondonORCID 0009-0008-8176-7161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Alyce McClellaniD· 1 shared Frances M. BrodskyiD· 1 shared George T. BatesiD· 1 shared Joshua GreigiD· 1 shared Kamila KamudaiD· 1 shared Konstantinos ThalassinosiD· 1 shared Leonie MülleriD· 1 shared María Emilia DueñasiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Alyce McClellanORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 7, 2026

Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter

George T. Bates, Will P. Bultitude, Joshua Greig…·Frances M. Brodsky

The paper identifies an alternatively-spliced form of CHC17 (CHC17-SAS) that compensates for the absence of CHC22 in some vertebrates, enabling GLUT4 trafficking.

DOI 10.64898/2026.08.20.745084

humanstructural biology

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Cell BiologyNature CommunicationsPeer-reviewedApr 11, 2025

Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex

Zhe Ji, Wingyan Skyla Siu, María Emilia Dueñas…·Pedro Carvalho

The paper identifies CTDNEP1-NEP1R1 as the R-SMAD phosphatase and shows how its complex with MAN1 inactivates TGF-β signaling by dephosphorylating R-SMADs in the nucleus.

7 citations

humanproteomics

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