Author

Sara Elfarrash

Mansoura UniversityORCID 0000-0002-4573-3131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Nanna Møller JenseniD· 3 shared Poul Henning JenseniD· 3 shared Cristine BetzeriD· 2 shared Nelson FerreiraiD· 2 shared Sadegh NabaviiD· 2 shared Ali ShaibiD· 1 shared Deniz KirikiD· 1 shared Donatus KrahiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Nanna Møller JensenORCID

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3 papers

Recent·Most cited

MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

Nanna Møller Jensen, YuHong Fu, Cristine Betzer, Hongyun Li, Sara Elfarrash, Ali Shaib, Donatus Krah, Zagorka Vitic, Lasse Reimer, Hjalte Gram, Vladimir L. Buchman, Mark Denham, Silvio O. Rizzoli, Glenda Margaret Halliday, Poul Henning Jensen

The paper introduces MJF-14 PLA, a proximity ligation assay for detecting non-inclusion alpha-synuclein aggregates with high specificity and sensitivity, showing pathology precedes Lewy body formation in Parkinson's disease.

npj Parkinson s Disease · Nov 29, 2024Peer-reviewedNeuroscience

Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Sissel Ida Schmidt, Emil Gregersen, Marie Vibeke Vestergaard, Sadegh Nabavi, Morten Meyer, Poul Henning Jensen

This study shows that PLK2 inhibition reduces soluble nuclear pS129 levels but not aggregated pS129 in synucleinopathy models.

PLoS ONE · Oct 6, 2021Peer-reviewedNeuroscience

Organotypic slice culture model demonstrates interneuronal spreading of alpha-synuclein aggregates

Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Cristine Betzer, Jervis Vermal Thevathasan, Robin Diekmann, Mohamed Adel, Nisreen Mansour Omar, Mohamed Z. Boraie, Sabry Gad, Jonas Ries, Deniz Kirik, Sadegh Nabavi, Poul Henning Jensen

The paper demonstrates that alpha-synuclein aggregates spread interneuronally in an organotypic hippocampal slice model, independent of serine 129 phosphorylation.

Acta Neuropathologica Communications · Dec 1, 2019Peer-reviewedNeuroscience