Xiuwen Zheng

FAVOR: Functional Annotation of Variants Online Resource and Annotator for Variation across the Human Genome

FAVOR provides an online resource and tool for functional annotation of variants from whole genome sequencing studies to aid in disease gene prioritization.

Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes

The paper performs single-variant and gene-based association analyses of 4,529 phenotypes using exome data from 426,370 UK Biobank individuals, finding associations linked to variant frequency and deleteriousness.

A meta-analysis of genome-wide association studies in 614,243 individuals identifies 59 novel susceptibility loci underlying Dupuytren's contracture

Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank

The paper describes exome sequencing of 200,643 UK Biobank participants, providing a rich resource of coding variants for genetic and drug discovery research.

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

The paper addresses variance stratification in pooled whole genome sequencing data, showing how study-specific phenotypic variances affect analysis and introducing a method to improve statistical power and reduce false positives.

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

The paper identifies genetic variants affecting HbA1c levels in multi-ancestry cohorts, showing ancestry-specific impacts on diabetes diagnosis via HbA1c.

A Fully-Adjusted Two-Stage Procedure for Rank Normalization in Genetic Association Studies

The paper introduces a fully-adjusted two-stage method for rank normalization in genetic association studies to reduce Type I errors and improve power by adjusting for covariates in both stages.