Marta Eugenia Alarcón-Riquelme

Interferon-α-Driven Stratification of B Cell Reveals Metabolic Reprogramming of Double Negative, Naive and Transitional cell subsets and Refines Molecular Classification in Söjgren's Disease.

This paper identifies an IFN-α signature in B cells of Sjögren's disease patients, revealing metabolic reprogramming and refining molecular classification.

A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney

This paper constructs a transcriptional patient map of SLE using single-cell and bulk RNA-seq data, identifying conserved immune programs in blood and kidney tissue.

The SjD Map: An interactive pathway tour into Sjogren's disease signalling mechanisms

The paper develops a molecular interaction map of Sjogren's disease using transcriptomic data and literature, integrating pathway analysis and experimental data for therapeutic insights.

BiomiX-Driven Multi-Omics Integration of PRECISESADS Data Reveals Lysophosphatidic Acid and Metabolic Pathway Signatures in B Cells and Immune Macroenvironment in Sjogren's Disease

This study integrates multi-omics data from Sjogren's disease patients to identify LPA and metabolic pathway signatures in B cells and the immune microenvironment.

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

The paper identifies five SNPs in the DDX6-CXCR5 locus associated with autoimmune diseases and shows their functional effects on gene regulation in immune and epithelial cells.

Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human Studies

This study evaluates molecular pathways in four spontaneous lupus mouse models and compares them to human SLE to assess translational relevance and guide future research.

BiomiX, a User-Friendly Bioinformatic Tool for Automatized Multiomics Data Analysis and Integration

BiomiX automates multiomics data analysis and integration, enabling efficient comparison of two cohorts through MOFA and providing interpretable results using literature and clinical data.

Systemic autoimmune disease patients' blood immunome reveals specificities and commonalities among different diagnostic entities

The paper uses immunophenotyping to identify patient subgroups in systemic autoimmune diseases, revealing shared immunophenotypes and cytokine signatures across different diagnoses.

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug Discovery

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

This study examines how a major genetic risk factor for COVID-19 affects mortality and severity, finding stronger effects in younger adults.

Continental-scale genomic analysis suggests shared post-admixture adaptation in Americas

The paper identifies shared post-admixture adaptation patterns in the Americas by analyzing genomic data from 6,000 admixed individuals, highlighting regions associated with immune response and disease traits.

A comprehensive and centralized database for exploring omics data in Autoimmune Diseases

ADEx is a database integrating omics data from autoimmune diseases, offering analysis tools for exploring transcriptomics and methylation studies.

An integrative multi-omics approach in Sjogrens Syndrome identifies novel genetic drivers with regulatory function and disease-specificity

This study identifies novel genetic drivers in Sjogrens Syndrome through an integrative multi-omics approach, revealing epigenetic signatures and regulatory variants associated with the disease.

The genomic impact of European colonization of the Americas

This study analyzes the genetic impact of European colonization on the Americas using genome-wide data from 12,000 individuals, revealing complex contributions from European, African, and other sources.