Guillermo Barturen

The paper identifies conserved miRNA-mRNA interactions in ticks that cooperatively target host genes involved in immune and tissue responses.

The paper uses single-nuclei RNA sequencing to analyze gonadal tissue from captive-bred and wild-bred male Senegalese sole, identifying impaired Sertoli-spermatogonia interactions as a cause of reduced sperm production and infertility.

This study integrates multi-omics data from Sjogren's disease patients to identify LPA and metabolic pathway signatures in B cells and the immune microenvironment.

This study evaluates molecular pathways in four spontaneous lupus mouse models and compares them to human SLE to assess translational relevance and guide future research.

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

BiomiX automates multiomics data analysis and integration, enabling efficient comparison of two cohorts through MOFA and providing interpretable results using literature and clinical data.

The paper uses immunophenotyping to identify patient subgroups in systemic autoimmune diseases, revealing shared immunophenotypes and cytokine signatures across different diagnoses.

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

ADEx is a database integrating omics data from autoimmune diseases, offering analysis tools for exploring transcriptomics and methylation studies.

The paper identifies four molecular clusters in systemic autoimmune diseases using transcriptome and methylome data, showing three stable aberrant patterns and one non-specific cluster.

This study identifies novel genetic drivers in Sjogrens Syndrome through an integrative multi-omics approach, revealing epigenetic signatures and regulatory variants associated with the disease.