Author

Jan-Malte Kleid

University Hospital CologneORCID 0000-0002-1400-653XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Frank KlawonniD· 2 shared Michael Damrat· 2 shared Milita DarguzyteiD· 2 shared Renata StripeckeiD· 2 shared Andreas SchneideriD· 1 shared Birgit Sybille GathofiD· 1 shared Brian W. Soper· 1 shared Britta Eiz-VesperiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Frank KlawonnORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 27, 2026

Next-generation all-in-one CRISPR/Cas9 multiply-edited CD30CAR-T cells:Potency despite risk of translocations

Jan-Malte Kleid, Michael Damrat, Milita Darguzyte…·Renata Stripecke

This study develops next-generation CD30CAR-T cells using CRISPR/Cas9 for multiplex editing, showing high potency but risks of translocations with combined knockouts.

DOI 10.64898/2026.02.27.708432

humanCITE-seq

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ImmunologyCellsPeer-reviewedOct 12, 2024

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

Milita Darguzyte, Philipp Antczak, Daniel Bachurski…·Renata Stripecke

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

6 citations

mouseexperimental assay

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