Author

Milita Darguzyte

University of CologneORCID 0000-0002-8213-8075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Frank KlawonniD· 3 shared Renata StripeckeiD· 3 shared Britta Eiz‐VesperiD· 2 shared Jan-Malte KleidiD· 2 shared Martin TheleniD· 2 shared Michael Damrat· 2 shared A. Ernst· 1 shared Andreas SchneideriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

Frank KlawonnORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Memory T Cells in MHC-Deficient Humanized Mice

Milita Darguzyte, Zhibek Zhumadilova, F. Khan, Masudur Rahman, S Sagar, A. Ernst, Isabel C. Poschke, Jonas Schulte-Schrepping, Elena De-Domenico, Marc Beyer, Dirk Schaudien, Anna Christina Dragon, Britta Eiz‐Vesper, Constantine von Kaisenberg, Frank Klawonn, , Renata Stripecke

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

bioRxiv · Aug 21, 2026 · PreprintImmunology

Next-generation all-in-one CRISPR/Cas9 multiply-edited CD30CAR-T cells:Potency despite risk of translocations

Jan-Malte Kleid, Michael Damrat, Milita Darguzyte, Manuel Rhiel, Natascha E. Stumpf, Tabea Kleitke, Sandra Ammann, Tatjana I. Cornu, Fawad Khan, Tobias Wollmann, Sven Borchmann, Christof Scheid, Christianne de Lima Borges Moraes, Tobias Riët, Sabine Awerkiew, , Renata Stripecke

This study develops next-generation CD30CAR-T cells using CRISPR/Cas9 for multiplex editing, showing high potency but risks of translocations with combined knockouts.

bioRxiv · Feb 27, 2026 · PreprintCancer Biology

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans Schlößer, Kerstin Wennhold, Martin Thelen, Maria Alejandra Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, , Renata Stripecke

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

Cells · Oct 12, 2024Peer-reviewedImmunology