Author

Daniel E. Zak

Center for Infectious Disease ResearchORCID 0000-0002-1404-400XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Ethan G. Thompson· 2 shared Fergal J. DuffyiD· 2 shared Thomas J. ScribaiD· 2 shared Andre Gareth LoxtoniD· 1 shared Elizna MaasdorpiD· 1 shared Gerard C. TrompiD· 1 shared Gerhard WalzliD· 1 shared Helena KuivaniemiiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Ethan G. Thompson

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2 papers

Recent·Most cited

GenomicsPLoS ONEPeer-reviewedDec 1, 2022

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

Stuart Meier, James A. Seddon, Elizna Maasdorp…·Gerard C. Tromp

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

17 citations

humanbulk RNA-seq

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Systems BiologyPLoS ONEPeer-reviewedJul 15, 2019

Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state.

Fergal J. Duffy, Ethan G. Thompson, Thomas J. Scriba, Daniel E. Zak

The paper develops a 10-gene random forest signature to predict TB and HIV status and distinguishes TB/HIV co-infection from other conditions with high accuracy.

23 citations

humanbulk RNA-seq

𝕏 PostBluesky