Fergal J. Duffy

Subunit vaccination enhances protection conferred by prior Mycobacterium tuberculosis exposure

This study shows that subunit vaccination provides better protection than BCG in Mtb-exposed individuals, supported by mouse models and human data.

Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence

This study shows that ferroptosis, a form of cell death, is enhanced by a virulent Mtb strain, SA161, and inhibiting it reduces bacterial spread in mice.

Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis

This study uses single-cell RNA sequencing to identify immune dynamics distinguishing protection from susceptibility to tuberculosis in mice.

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state.

The paper develops a 10-gene random forest signature to predict TB and HIV status and distinguishes TB/HIV co-infection from other conditions with high accuracy.