Author

James A. Seddon

Stellenbosch UniversityORCID 0000-0002-2296-2302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

A-M. Demers· 1 shared Andre Gareth LoxtoniD· 1 shared Andrew Christopher WhitelawiD· 1 shared Anneke Catharina HesselingiD· 1 shared Daniel E. ZakiD· 1 shared Elizna MaasdorpiD· 1 shared Ethan G. Thompson· 1 shared Fergal J. DuffyiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A-M. Demers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The impact of long-term levofloxacin on the bacterial gut microbiome of young South African children

Kristien Nel Van Zyl, Andrew Christopher Whitelaw, Anneke Catharina Hesseling, James A. Seddon, A-M. Demers, Mae Newton-Foot

This study examines how long-term levofloxacin affects gut microbiota in young children, finding that infants experience stunted microbial diversification that persists after treatment.

bioRxiv · Feb 4, 2026 · PreprintMicrobiology

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

Stuart Meier, James A. Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre Gareth Loxton, Stephanus Theron Malherbe, Daniel E. Zak, Ethan G. Thompson, Fergal J. Duffy, Stefan H. E. Kaufmann, Tom H. M. Ottenhoff, Thomas J. Scriba, Sara Suliman, Jayne S. Sutherland, , Gerard C. Tromp

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

PLoS ONE · Dec 1, 2022Peer-reviewedGenomics