S100A9-Dependent CXCR2hi Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC
Fulya Koksalar Alkan, Ahmet B. Çağlayan, Hilmi Kaan Alkan…·Hasan Körkaya
This paper identifies a TGF-β/S100A9/CXCR2 axis in metastatic TNBC that drives neutrophil expansion and immune suppression, with S100A9 loss enhancing immunotherapy response.