Author

Javier Sotillo

Australian Institute of Tropical Health and MedicineORCID 0000-0002-1443-7233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex C. LoukasiD· 4 shared Paul J. BrindleyiD· 3 shared Thewarach LahaiD· 3 shared Banchob SripaiD· 2 shared Christina J. CochraniD· 2 shared Michael J. SmoutiD· 2 shared Patpicha ArunsaniD· 2 shared Shannon E. KarinshakiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Alex C. LoukasORCID

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Author profile →

4 papers

Recent·Most cited

Fluke-borne viruses are a risk factor and diagnostic target for diseases caused by carcinogenic trematodes

Sujittra Chaiyadet, Tom Roblin, Anaïs Fauchois, Sarah Temmam, David Hing, Elise Jacquemet, Thomas Bigot, Blaise Li, Julia Kende, Lisandru Capai, Javier Sotillo, Thewarach Laha, Sophie Goyard, David Hardy, Thierry Rose, , Nolwenn Marie Dheilly

The paper identifies fluke-borne viruses as risk factors and diagnostic targets for cancers caused by carcinogenic trematodes.

bioRxiv · Oct 22, 2025 · PreprintMicrobiology

Liver fluke granulin promotes exosome-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma

Patpicha Arunsan, Apisit Chaidee, Christina J. Cochran, Victoria H. Mann, Toshihiko Tanno, Chutima Kumkhaek, Michael J. Smout, Shannon E. Karinshak, Rutchanee Rodpai, Javier Sotillo, Alex C. Loukas, Thewarach Laha, Paul J. Brindley, Wannaporn Ittiprasert

The paper investigates how liver fluke granulin promotes exosome-mediated crosstalk that alters the cellular microenvironment to support cholangiocarcinoma development.

Neoplasia · Mar 31, 2020Peer-reviewedMolecular Biology

Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling, glucose scavenging and drug detoxification and are essential for parasite survival

Bemnet Tedla, Javier Sotillo, Darren Pickering, Ramon M. Eichenberger, Stephanie M. Ryan, Luke Becker, Alex C. Loukas, Mark S. Pearson

This study identifies and characterizes three cholinesterase genes in Schistosoma mansoni, showing their roles in neurotransmission, glucose scavenging, and drug detoxification, with essential functions for parasite survival.

PLoS Pathogens · Dec 6, 2019Peer-reviewedMolecular Biology

Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity

Patpicha Arunsan, Wannaporn Ittiprasert, Michael J. Smout, Christina J. Cochran, Victoria H. Mann, Sujittra Chaiyadet, Shannon E. Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo, Alex C. Loukas, Paul J. Brindley, Thewarach Laha

This study uses CRISPR/Cas9 to knockout the Ov-grn-1 gene in liver flukes, showing reduced biliary tract pathology in infected hamsters.

eLife · Jan 14, 2019Peer-reviewedMolecular Biology