Alex C. Loukas

Plant Molecules Protect Against Inflammatory Bowel Disease by Restoring Gut Microbiota-Immune Homeostasis and Suppressing Pro-inflammatory Markers

This study identifies Garcinia brassii metabolites that reduce inflammation and restore gut microbiota balance in IBD, with garcinia biflavonoid 1 and parvifoliol F showing therapeutic potential.

Fluke-borne viruses are a risk factor and diagnostic target for diseases caused by carcinogenic trematodes

The paper identifies fluke-borne viruses as risk factors and diagnostic targets for cancers caused by carcinogenic trematodes.

Liver fluke granulin promotes exosome-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma

The paper investigates how liver fluke granulin promotes exosome-mediated crosstalk that alters the cellular microenvironment to support cholangiocarcinoma development.

Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling, glucose scavenging and drug detoxification and are essential for parasite survival

This study identifies and characterizes three cholinesterase genes in Schistosoma mansoni, showing their roles in neurotransmission, glucose scavenging, and drug detoxification, with essential functions for parasite survival.

Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity

This study uses CRISPR/Cas9 to knockout the Ov-grn-1 gene in liver flukes, showing reduced biliary tract pathology in infected hamsters.