David Hardy

This study targets the Sec61 translocon to suppress pathogenic light-chain production in AL amyloidosis, showing that mycolactone and synthetic inhibitors like A317 reduce LC secretion while highlighting the need for client selectivity.

This study evaluates monoclonal antibodies RVC20 and RVC58 for treating symptomatic rabies in mice, showing that intravenous and intramuscular administration can clear viral infection and improve survival, with RVC58 achieving 80% survival.

The paper identifies dysregulated dsRNA sensing and RNA viral exposure as potential triggers of type I interferon dysregulation in juvenile dermatomyositis onset.

This study compares aerosol and subcutaneous vaccination with BCG and BCG::ESX-1Mmar, finding aerosol vaccination enhances immune responses and protection against tuberculosis in mice.

This study creates a spatial transcriptomic atlas of the developing mouse cochlea to identify gene expression gradients and cell-type specific signatures linked to cochlear function.

The paper identifies fluke-borne viruses as risk factors and diagnostic targets for cancers caused by carcinogenic trematodes.

This paper modifies a measles vaccine by removing a viral protein to create a cancer immunotherapy that activates the immune system via RIG-I signaling, leading to tumor regression in multiple models.

This study shows that SARS-CoV-2 infects and persists in hamster brainstem, causing neurodegenerative and immunometabolic changes linked to neuropsychiatric and cognitive symptoms.

This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.

This study uses a recombinant CHIKV-NLuc virus in a mouse model to show CHIKV infects chondrocytes, leading to apoptosis and inflammation in joints, contributing to chronic arthritis.

This study identifies myocarditis and neutrophil-mediated vascular leakage as key factors in fatal murine leptospirosis, distinct from cytokine storm or organ failure.

This paper uses conditional generative models to transform cell images between conditions, revealing hidden phenotypes by removing natural cell variability.

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

This study shows that genetic diversity in Collaborative Cross mice affects ZIKV infection outcomes, including viral replication and disease severity, independent of Oas1b.