Victoria H. Mann

The paper demonstrates that CRISPR/Cas12a with modified transgenes achieves more efficient gene knock-in in Schistosoma mansoni compared to Cas9.

The paper identifies and characterizes genomic safe harbor sites in Schistosoma mansoni to enable consistent transgene activity through CRISPR/Cas-assisted homology-directed repair.

This paper identifies and characterizes SmNAGAL, a glycosyl hydrolase in Schistosoma mansoni, showing its role in coordinating parasite movement and egg production, suggesting it as a potential target for new anthelmintic drugs.

This study compares the efficiency of Cas12a and Cas9 for gene knockout and knock-in in Schistosoma mansoni, finding AsCas12a more efficient for knockout but SpCas9 more precise for knock-in.

The paper investigates how PIWI and retrotransposon nimbus interact to modulate resistance to Schistosoma mansoni in Biomphalaria glabrata snails through epigenetic mechanisms.

This paper uses CRISPR/Cas9 to edit the acetylcholinesterase gene in Schistosoma mansoni eggs, resulting in reduced AChE activity and decreased granuloma size in mice.

The paper shows that CagA+ Helicobacter pylori infection induces epithelial to mesenchymal transition in human cholangiocytes, promoting migration, invasion, and colony formation.

This paper uses CRISPR/Cas9 to knockout the BgAIF gene in Bge cells, showing reduced adherence to Schistosoma mansoni sporocysts.

The paper investigates how liver fluke granulin promotes exosome-mediated crosstalk that alters the cellular microenvironment to support cholangiocarcinoma development.

This paper demonstrates CRISPR/Cas9-based genome editing in Schistosoma mansoni, successfully mutating the omega-1 gene and reducing Th2 cytokine responses and granuloma formation.

This study uses CRISPR/Cas9 to knockout the Ov-grn-1 gene in liver flukes, showing reduced biliary tract pathology in infected hamsters.