This study identifies five novel UBA5 inhibitors through HTS, showing selectivity and efficacy in inhibiting UFMylation, with potential for therapeutic applications in neurodegenerative diseases and cancer.

1 citation

humanexperimental assay

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NeuroscienceACS Chemical BiologyPeer-reviewedNov 18, 2025

High-Throughput Screening and Initial SAR Studies Identify a Novel Sub-micromolar Potent Human cGAS Inhibitor

Jazmín Alarcón‐Espósito, Ravi Kumar Nagiri, Siyu Wang…·Subhash C. Sinha

The paper identifies a potent human cGAS inhibitor through high-throughput screening and SAR analysis, showing sub-micromolar activity and partial inhibition of cGAMP levels.

2 citations

humanexperimental assay

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BiophysicsNature CommunicationsPeer-reviewedSep 4, 2024

Small LEA proteins as an effective air-water interface protectant for fragile samples during cryo-EM grid plunge freezing

Kaitlyn M. Abe, Li Gan, Qixiang He…·Ci Ji Lim

The paper shows small LEA proteins protect fragile samples from air-water interface damage during cryo-EM plunge freezing, improving structural determination of multisubunit complexes.

28 citationstop 4%

cryo-EMexperimental assay

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