Author

Chad A. Cowan

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alan R. SandersiD· 1 shared Alena KozlovaiD· 1 shared Andrian YangiD· 1 shared Christine RowleyiD· 1 shared Faith Thomas· 1 shared Florian T. MerkleiD· 1 shared G. Grant Welstead· 1 shared Gao T. WangiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperGenetics

Alan R. SandersORCID

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Author profile →

3 papers

Recent·Most cited

Universal protection of allogeneic cell therapies from natural killer cells via CD300a agonism

Shuqi Zhang, Faith Thomas, Justin W. Fang, Kathryn Austgen, Chad A. Cowan, G. Grant Welstead

This paper develops CD300a TASR, an engineered ligand that universally protects HLA-deficient allogeneic T cells from NK cell rejection and enhances CAR-T efficacy.

Blood Advances · Oct 5, 2024Peer-reviewedImmunology

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

Hsiao‐Jou Cortina Chen, Andrian Yang, Simone Mazzaferro, Iman D. Mali, Olivier Cahn, Katherine A. Kentistou, Christine Rowley, Natasha M. Stewart, Jun Wen Eugene Seah, Venkat Pisupati, Peter Kirwan, Sanya Aggarwal, Takafumi Toyohara, Mary H.C. Florido, Chad A. Cowan, , Florian T. Merkle

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience

Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants

Siwei Zhang, Hanwen Zhang, Min Qiao, Yifan Zhou, Siming Zhao, Alena Kozlova, Jianxin Shi, Alan R. Sanders, Gao T. Wang, Subhajit Sengupta, Siobhan West, Michael Streit, Chad A. Cowan, Mengjie Chen, Zhiping P. Pang, , Jubao Duan

The paper identifies allele-specific open chromatin (ASoC) variants in human iPSC-derived neurons and shows their strong enrichment in brain disorder risk variants.

bioRxiv · Nov 1, 2019 · PreprintGenetics