Igor R. Efimov

This paper introduces a mesoscale soft robotic interface to apply mechanical forces to human organoids and monitor their physiological responses, revealing distinct mechanical and electrophysiological behaviors in cortical and cardiac organoids.

The paper quantifies TATS ultrastructural features across eight mammalian species and finds correlations between TATS density, cardiomyocyte size, and physiological parameters like heart rate and lifespan.

This study shows that p38β deficiency worsens cardiac structure, electrophysiology, and immune function in aged mice, highlighting its protective role in aging hearts.

This study shows that Tbx3 and Tbx5 work together to control the function and molecular identity of the adult ventricular conduction system in mice, leading to conduction defects when both are missing.

This paper develops a Seahorse-based protocol to assess metabolic fuel usage in cardiac organotypic slices from human and mouse, showing its sensitivity and applicability across species.

The paper creates a comprehensive neuroanatomic atlas of the RAGP-SAN complex in porcine and human hearts, showing how intrinsic cardiac neurons control SAN automaticity and cardiac function.

The paper presents a comprehensive CAGE atlas of human cardiac promoters and enhancers, identifying novel regulatory elements and their association with heart morphology and pathologies.

This paper demonstrates that a heart slice culture system reliably detects drug-induced cardiotoxicity mechanisms in anti-cancer drugs.

This study compares four ablation protocols in human left ventricular tissue, finding that cryo-radiofrequency ablation (CR-RF) produces the deepest lesion.