Jesse D. Kirkpatrick

The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.

This paper develops a 3D in vitro model of the human hepatobiliary junction that recapitulates bile flow and dysfunction under hypoxia-reoxygenation, offering insights into biliary pathophysiology.

This study identifies Wnt9b-Sfrp2 crosstalk between endothelial and stellate cells as a driver of fibrosis resolution in MASH using single-cell and spatial profiling.

This paper engineers multiplexed synthetic breath biomarkers to detect disease-specific protease activities and applies them to diagnose lung cancer and monitor treatment response in mice.

A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.