Sahil Patel

Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception

The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.

Molecular determinants of antibody-mediated priming to enhance detection of ctDNA

This paper identifies molecular features of monoclonal antibodies that enhance ctDNA detection by increasing its concentration in blood.

Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes

This paper engineers multiplexed synthetic breath biomarkers to detect disease-specific protease activities and applies them to diagnose lung cancer and monitor treatment response in mice.

An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies

A DNA-binding agent increases cfDNA levels in blood, improving ctDNA detection and cancer sensitivity in mice.

A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies

A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.