Cathy S. Wang

The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.

This paper engineers multiplexed synthetic breath biomarkers to detect disease-specific protease activities and applies them to diagnose lung cancer and monitor treatment response in mice.

The paper introduces PAA, a toolkit for analyzing protease activity data, offering preprocessing, visualization, and machine learning tools to standardize analysis across in vitro and in vivo assays.