This study identifies Wnt9b-Sfrp2 crosstalk between endothelial and stellate cells as a driver of fibrosis resolution in MASH using single-cell and spatial profiling.

Cell Reports · Jan 23, 2026Peer-reviewedMolecular Biology

In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis

Chittampalli N. Yashaswini, Bruno Cogliati, Tianyue Qin, Tran To, Thomas Williamson, Tyler Ellis Papp, Kenneth Li, Raisa B. Rasul, Li Chen, Adi Lightstone, Haig K. Aghajanian, Hamideh Parhiz, Shuang Wang, Joel G. Rurik, Jonathan A. Epstein, Scott L. Friedman

This study evaluates in vivo anti-FAP CAR T therapy for MASH, showing reduced fibrosis and restored liver homeostasis through HSC depletion and immune modulation.

bioRxiv · Feb 25, 2025 · PreprintCell Biology

Constitutive and conditional epitope-tagging of endogenous G protein coupled receptors in Drosophila

Shivan L. Bonanno, Piero Sanfilippo, Aditya Eamani, Maureen McGuirk Sampson, Binu Kandagedon, Kenneth Li, Giselle D. Burns, Marylyn E. Makar, S Lawrence Zipursky, David E. Krantz

The paper develops a method to tag endogenous GPCRs in Drosophila for localization studies and uses it to investigate receptor distribution and function in neural circuits.

Journal of Neuroscience · Jun 27, 2024Peer-reviewedNeuroscience