Author

Johanna Bruce

Centre National de la Recherche ScientifiqueORCID 0000-0002-1522-9604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genetics· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Anne BigotiD· 2 shared Capucine TrolletiD· 2 shared Elisa NégroniiD· 2 shared Emilie‐Fleur GautieriD· 2 shared Jessica OhanaiD· 2 shared Mona BensalahiD· 2 shared Abdoulaye SissokoiD· 1 shared Alexis BoulinguieziD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Anne BigotORCID

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Author profile →

4 papers

Recent·Most cited

Aging remodels the human muscle secretome, impairing stem cell via sphingolipid metabolism

Bárbara Crisol, Natalia Pinzón, Mona Bensalah, Jessica Ohana, Marie Lhomme, Maharajah Ponnaiah, Johanna Bruce, Maria Kondili, Ludovic Gaut, Elisa Négroni, Alexis Boulinguiez, Gillian Sandra Butler-Browne, Vincent Mouly, Capucine Trollet, Anne Bigot

This study identifies age-related changes in the muscle secretome that impair stem cell function through sphingolipid metabolism alterations.

bioRxiv · Oct 2, 2026 · PreprintCell Biology

EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne Muscular Dystrophy

Maeva Zamperoni, Laura Muraine, Minh-Y Tran, Alice Granados, Anne Bigot, Valentin Petit, Mona Bensalah, Jessica Ohana, Véronique Legros, Ekaterina Boyarchuk, Johanna Bruce, Guillaume Chevreux, Véronique Joliot, Elisa Négroni, Maryline Moulin, , Slimane Ait‐Si‐Ali

The paper identifies EMILIN1 as a TGFβ/SETDB1-regulated secreted biomarker in DMD, showing its role in fibrosis and myogenesis through proteomic analysis of patient-derived myotubes.

Cell Death and Disease · May 9, 2026Peer-reviewedGenetics

The protein-protein interaction landscape of Fanconi anemia protein A (FANCA) reveals its contributions to mRNA processes.

Virgile Gibert, Frédérique Maczkowiak, Benedetta Mancini, Emilie‐Fleur Gautier, Johanna Bruce, Morgane Le Gall, Serge Urbach, Angelos Constantinou, Anne Helbling-Leclerc, Jihane Basbous, Filippo Rosselli

The paper identifies new protein interactions of FANCA, revealing its roles in mRNA processes beyond DNA repair, and suggests potential therapeutic targets for Fanconi anemia.

bioRxiv · Sep 11, 2025 · PreprintGenetics

Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance

Sandy Peltier, Mickaël Marin, Monika Dzieciątkowska, Michaël Dussiot, Micaela Kalani Roy, Johanna Bruce, Louise Leblanc, Youcef Hadjou, Sonia Georgeault, Aurélie Fricot, Camille Roussel, Daniel Stephenson, Madeleine Casimir, Abdoulaye Sissoko, François Paye, , Pascal Amireault

This study identifies molecular and cellular changes in storage-induced senescent erythrocytes (SMEs) that lead to their clearance, showing altered metabolism, proteostasis, and membrane properties.

Journal of Clinical Investigation · Mar 11, 2025Peer-reviewedCell Biology