Véronique Legros

MYC and MAX drive the reactivation of the genome after mitosis

This study identifies MYC and MAX as critical for post-mitotic genome reactivation in pluripotent mouse embryonic stem cells, showing MAX's role in bookmarking and MYC recruitment.

Cyclin B phosphorylation by PKA safeguards the G2-arrest in vertebrate oocytes

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

Low-input proteomics enables proteome and phosphoproteome-scale molecular phenotyping of separase-deficient oocytes

The paper uses low-input proteomics to compare proteome and phosphoproteome changes in wild-type and separase-deficient mouse oocytes, revealing specific alterations in chromosome-associated proteins.

Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events

This study shows that Greatwall kinase coordinates meiotic divisions by regulating PP2A-B55, which controls APC/C and Mos/MAPK pathways in Xenopus oocytes.

EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne Muscular Dystrophy

The paper identifies EMILIN1 as a TGFβ/SETDB1-regulated secreted biomarker in DMD, showing its role in fibrosis and myogenesis through proteomic analysis of patient-derived myotubes.

An RNA-centric interactomics screen identifies novel proviral and antiviral genome binding interactors for tick-borne encephalitis virus

The paper identifies novel host factors interacting with TBEV RNA through an RNA-centric screen, revealing both proviral and antiviral proteins involved in viral replication and immune evasion.

Molecular dialogue between Orthonairovirus and tick: RNA-protein interactome of Hazara virus, a BSL2 model of Crimean-Congo Hemorrhagic Fever virus, in Hyalomma cells

This study identifies RNA-protein interactions between Hazara virus and Hyalomma tick proteins using ChIRP-MS, revealing mitochondrial RNA-binding proteins involved in metabolic pathways.

A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition

This study identifies Reg1 mutations that confer resistance to 2-deoxyglucose in yeast by disrupting its role in Snf1 inhibition.

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

The nuclear PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium

The paper identifies Gtsf1 as essential for selecting and degrading small RNAs in Paramecium, ensuring proper genome elimination during macronucleus development.